Association of abstinence-induced alterations in working memory function and COMT genotype in smokers.

ABSTRACT:

Rationale

The common methionine (met) for valine (val) at codon 158 (val(158)met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with nicotine dependence, alterations in executive cognitive function, and abstinence-induced working memory deficits in smokers.

Objectives

We sought to replicate the association of the COMT val allele with abstinence-induced alterations in working memory-related activity in task-positive (executive control) and task-negative (default mode network) regions.

Methods

Forty smokers (20 val/val and 20 met/met) performed an N-back task while undergoing blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) on two separate occasions: following 72 h of confirmed abstinence and during smok

SUBMITTER: Ashare RL 

PROVIDER: S-EPMC3840089 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature