MRAS Genetic Variation Is Associated with Atherothrombotic Stroke in the Han Chinese Population.

ABSTRACT:

Background and purpose

Atherothrombotic cerebral infarction [atherothrombotic stroke (ATS)] shares common risk factors and pathophysiological mechanisms with coronary artery disease (CAD), and both diseases appear to have common susceptibility loci. The muscle RAS oncogene homolog gene (MRAS) has been identified as a susceptibility locus for CAD and is implicated in atherosclerosis. The aim of this study was to elucidate whether the single-nucleotide polymorphisms (SNPs) and haplotypes of MRAS are associated with increased risk of ATS in a population of Han Chinese.

Methods

A case-controlled association study was conducted in which only patients with ATS (identified as a major subtype in the Korean modification of the Trial of Org 10172 in Acute Stroke Treatment classificati

SUBMITTER: Liu H 

PROVIDER: S-EPMC3840132 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature