Gene expression data reveal common pathways that characterize the unifocal nature of ovarian cancer.

ABSTRACT:

Objective

The objective of the study was to evaluate the biological validity of ovarian cancer (OVCA) screening and early detection efforts and to characterize signaling pathways associated with human cancer metastasis and patient survival.

Study design

Using genome-wide expression profiling and deoxyribonucleic acid sequencing, we compared pelvic and matched extrapelvic implants from 30 patients with advanced-stage OVCA for expression of molecular signaling pathways and p53 gene mutations. Differentially expressed pathways were further evaluated in a series of primary or early-stage vs metastatic or recurrent cancer samples from 389 ovarian, prostate, and oral cancer patients. Metastasis pathways were also evaluated for associations with survival in 9 independent clinicogen

SUBMITTER: Marchion DC 

PROVIDER: S-EPMC3840156 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature