Long-term colorectal-cancer incidence and mortality after lower endoscopy.

ABSTRACT:

Background

Colonoscopy and sigmoidoscopy provide protection against colorectal cancer, but the magnitude and duration of protection, particularly against cancer of the proximal colon, remain uncertain.

Methods

We examined the association of the use of lower endoscopy (updated biennially from 1988 through 2008) with colorectal-cancer incidence (through June 2010) and colorectal-cancer mortality (through June 2012) among participants in the Nurses' Health Study and the Health Professionals Follow-up Study.

Results

Among 88,902 participants followed over a period of 22 years, we documented 1815 incident colorectal cancers and 474 deaths from colorectal cancer. With endoscopy as compared with no endoscopy, multivariate hazard ratios for colorectal cancer were 0.57 (95% co

SUBMITTER: Nishihara R 

PROVIDER: S-EPMC3840160 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature