Ontology highlight
ABSTRACT:
SUBMITTER: Masui K
PROVIDER: S-EPMC3840163 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Cell metabolism 20131017 5
Aerobic glycolysis (the Warburg effect) is a core hallmark of cancer, but the molecular mechanisms underlying it remain unclear. Here, we identify an unexpected central role for mTORC2 in cancer metabolic reprogramming where it controls glycolytic metabolism by ultimately regulating the cellular level of c-Myc. We show that mTORC2 promotes inactivating phosphorylation of class IIa histone deacetylases, which leads to the acetylation of FoxO1 and FoxO3, and this in turn releases c-Myc from a supp ...[more]