Vitamin D status and TB treatment outcomes in adult patients in Tanzania: a cohort study.

ABSTRACT:

Objectives

Vitamin D is an immunomodulator and can alter response to tuberculosis (TB) treatment, though randomised trials have been inconclusive to date. We present one of the first comprehensive analysis of the associations between vitamin D status and TB treatment, T-cell counts and nutritional outcomes by HIV status.

Design

Cohort study.

Setting

Outpatient clinics in Tanzania.

Participants

25-hydroxyvitamin D levels were assessed in a cohort of 677 patients with TB (344 HIV infected) initiating anti-TB treatment at enrolment in a multivitamin supplementation (excluding vitamin D) trial (Clinicaltrials.gov identifier: NCT00197704).

Primary and secondary outcome measures

Information on treatment outcomes such as failure and relapse, HIV disease progres

SUBMITTER: Mehta S 

PROVIDER: S-EPMC3840339 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature