Lung Cancer Susceptibility and hOGG1 Ser326Cys Polymorphism: A Meta-Analysis.

ABSTRACT: Recent lung cancer studies have focused on identifying the effects of single nucleotide polymorphisms (SNPs) in candidate genes, among which DNA repair genes are increasingly being studied. Genetic variations in DNA repair genes are thought to modulate DNA repair capacity and are suggested to be related to lung cancer risk. In this study, we tried to assess reported studies of association between polymorphism of human 8-oxoguanine DNA glycosylase 1 (hOGG1) Ser326Cys and lung cancer. We conducted MEDLINE, Current Contents and Web of Science searches using "hOGG1", "lung cancer" and "polymorphism" as keywords to search for papers published (from January 1995 through August 2010). Data were combined using both a fixed effects (the inverse variance-weighted method) and a random effects (DerSim

SUBMITTER: Kiyohara C 

PROVIDER: S-EPMC3840447 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature