Lipid pools as photolabile "protecting groups": design of light-activatable bioagents.

ABSTRACT: Inactive in the membrane: Lipidated light-responsive constructs that sequester bioagents (R, see scheme) to the membranes of organelles and cells have been constructed. When membrane-bound, the bioagent is not susceptible to processing by its biological target. Photolysis releases the bioagent from its membrane anchor and thereby renders it biologically active.

SUBMITTER: Nguyen LT 

PROVIDER: S-EPMC3840492 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature