Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression.

ABSTRACT:

Background

Debate is ongoing about what role, if any, variation in the serotonin transporter linked polymorphic region (5-HTTLPR) plays in depression. Some studies report an interaction between 5-HTTLPR variation and stressful life events affecting the risk for depression, others report a main effect of 5-HTTLPR variation on depression, while others find no evidence for either a main or interaction effect. Meta-analyses of multiple studies have also reached differing conclusions.

Methods/design

To improve understanding of the combined roles of 5-HTTLPR variation and stress in the development of depression, we are conducting a meta-analysis of multiple independent datasets. This coordinated approach utilizes new analyses performed with centrally-developed, standardized script

SUBMITTER: Culverhouse RC 

PROVIDER: S-EPMC3840571 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature