Growth rate-coordinated transcriptome reorganization in bacteria.

ABSTRACT:

Background

Cell growth rate reflects an organism's physiological state and largely relies on the ability of gene expression to respond to the environment. The relationship between cellular growth rate and gene expression remains unknown.

Results

Growth rate-coordinated changes in gene expression were discovered by analyzing exponentially growing Escherichia coli cells cultured under multiple defined environments, in which osmotic pressure, temperature and starvation status were varied. Gene expression analyses showed that all 3,740 genes in the genome could be simply divided into three clusters (C1, C2 and C3), which were accompanied by a generic trend in the growth rate that was coordinated with transcriptional changes. The direction of transcriptional change in C1 indicate

SUBMITTER: Matsumoto Y 

PROVIDER: S-EPMC3840594 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature