The Drosophila early ovarian transcriptome provides insight to the molecular causes of recombination rate variation across genomes.

ABSTRACT:

Background

Evidence in yeast indicates that gene expression is correlated with recombination activity and double-strand break (DSB) formation in some hotspots. Studies of nucleosome occupancy in yeast and mice also suggest that open chromatin influences the formation of DSBs. In Drosophila melanogaster, high-resolution recombination maps show an excess of DSBs within annotated transcripts relative to intergenic sequences. The impact of active transcription on recombination landscapes, however, remains unexplored in a multicellular organism. We then investigated the transcription profile during early meiosis in D. melanogaster females to obtain a glimpse at the relevant transcriptional dynamics during DSB formation, and test the specific hypothesis that DSBs preferentially target tr

SUBMITTER: Adrian AB 

PROVIDER: S-EPMC3840681 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature