Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover.

ABSTRACT: Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers. Hedgehog signaling has an unusual reception system consisting of two transmembrane proteins, Patched receptor and Smoothened signal transducer. Although activation of Smoothened and its downstream signal transduction have been intensively studied, less is known about how Patched receptor is regulated, and particularly how this regulation contributes to appropriate Hedgehog signal transduction. Here we identified a novel role of Smurf E3 ligase in regulating Hedgehog signaling by controlling Patched ubiquitination and turnover. Moreover, we showed that Smurf-mediated Patched ubiquitination depends on Smo activity in wing discs. Mechan

SUBMITTER: Huang S 

PROVIDER: S-EPMC3841102 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature