Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC3841137 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Xu Yan Y Ohms Stephen J SJ Li Zhen Z Wang Qiao Q Gong Guangming G Hu Yiqiao Y Mao Zhiyong Z Shannon M Frances MF Fan Jun Y JY
PloS one 20131126 11
Multidrug resistance (MDR) frequently develops in cancer patients exposed to chemotherapeutic agents and is usually brought about by over-expression of P-glycoprotein (P-gp) which acts as a drug efflux pump to reduce the intracellular concentration of the drug(s). Thus, inhibiting P-gp expression might assist in overcoming MDR in cancer chemotherapy. MiRNAome profiling using next-generation sequencing identified differentially expressed microRNAs (miRs) between parental K562 cells and MDR K562 c ...[more]