The gastric CB1 receptor modulates ghrelin production through the mTOR pathway to regulate food intake.

ABSTRACT: Over the years, the knowledge regarding the relevance of the cannabinoid system to the regulation of metabolism has grown steadily. A central interaction between the cannabinoid system and ghrelin has been suggested to regulate food intake. Although the stomach is the main source of ghrelin and CB1 receptor expression in the stomach has been described, little information is available regarding the possible interaction between the gastric cannabinoid and ghrelin systems in the integrated control of energy homeostasis. The main objective of the present work was to assess the functional interaction between these two systems in terms of food intake using a combination of in vivo and in vitro approaches. The present work demonstrates that the peripheral blockade of the CB1 receptor by rimonaban

SUBMITTER: Senin LL 

PROVIDER: S-EPMC3841176 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature