Prioritization of cancer marker candidates based on the immunohistochemistry staining images deposited in the human protein atlas.

ABSTRACT: Cancer marker discovery is an emerging topic in high-throughput quantitative proteomics. However, the omics technology usually generates a long list of marker candidates that requires a labor-intensive filtering process in order to screen for potentially useful markers. Specifically, various parameters, such as the level of overexpression of the marker in the cancer type of interest, which is related to sensitivity, and the specificity of the marker among cancer groups, are the most critical considerations. Protein expression profiling on the basis of immunohistochemistry (IHC) staining images is a technique commonly used during such filtering procedures. To systematically investigate the protein expression in different cancer versus normal tissues and cell types, the Human Protein Atlas i

SUBMITTER: Chiang SC 

PROVIDER: S-EPMC3841220 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature