Cost-effectiveness analysis of coronary artery disease screening in HIV-infected men.

ABSTRACT:

Background

HIV-infected patients are at increased risk of coronary artery disease (CAD). We evaluated the cost-effectiveness of cardiac screening for HIV-positive men at intermediate or greater CAD risk.

Design

We developed a lifetime microsimulation model of CAD incidence and progression in HIV-infected men.

Methods

Input parameters were derived from two HIV cohort studies and the literature. We compared no CAD screening with stress testing and coronary computed tomography angiography (CCTA)-based strategies. Patients with test results indicating 3-vessel/left main CAD underwent invasive coronary angiography (ICA) and received coronary artery bypass graft surgery. In the stress testing + medication and CCTA + medication strategies, patients with 1-2-vessel CAD result

SUBMITTER: Nolte JE 

PROVIDER: S-EPMC3841232 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature