Integrative pathway analysis of a genome-wide association study of (V)O(2max) response to exercise training.

ABSTRACT: We previously reported the findings from a genome-wide association study of the response of maximal oxygen uptake (Vo2max) to an exercise program. Here we follow up on these results to generate hypotheses on genes, pathways, and systems involved in the ability to respond to exercise training. A systems biology approach can help us better establish a comprehensive physiological description of what underlies Vo2maxtrainability. The primary material for this exploration was the individual single-nucleotide polymorphism (SNP), SNP-gene mapping, and statistical significance levels. We aimed to generate novel hypotheses through analyses that go beyond statistical association of single-locus markers. This was accomplished through three complementary approaches: 1) building de novo evidence of gen

SUBMITTER: Ghosh S 

PROVIDER: S-EPMC3841836 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature