A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies.

ABSTRACT:

Importance

While mutations in glucocerebrosidase (GBA1) are associated with an increased risk for Parkinson disease (PD), it is important to establish whether such mutations are also a common risk factor for other Lewy body disorders.

Objective

To establish whether GBA1 mutations are a risk factor for dementia with Lewy bodies (DLB). DESIGN We compared genotype data on patients and controls from 11 centers. Data concerning demographics, age at onset, disease duration, and clinical and pathological features were collected when available. We conducted pooled analyses using logistic regression to investigate GBA1 mutation carrier status as predicting DLB or PD with dementia status, using common control subjects as a reference group. Random-effects meta-analyses were conducted t

SUBMITTER: Nalls MA 

PROVIDER: S-EPMC3841974 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature