Mesoporous silicon microparticles enhance MHC class I cross-antigen presentation by human dendritic cells.

ABSTRACT: The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.

SUBMITTER: Jimenez-Perianez A 

PROVIDER: S-EPMC3842076 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature