TOX4 and NOVA1 proteins are partners of the LEDGF PWWP domain and affect HIV-1 replication.

ABSTRACT: PWWP domains are involved in the chromatin attachment of several proteins. They bind to both DNA and proteins and their interaction with specific histone methylation marks define them as a new class of histone code readers. The lens epithelium derived growth factor (LEDGF/p75) contains an N-terminal PWWP domain necessary for its interaction with chromatin but also a C-terminal domain which interacts with several proteins, such as lentiviral integrases. These two domains confer a chromatin-tethering function to LEDGF/p75 and in the case of lentiviral integrases, this tethering participates in the efficiency and site selectivity of integration. Although proteins interacting with LEDGF/p75 C-terminal domain have been extensively studied, no data exist about partners of its PWWP domain regulat

SUBMITTER: Morchikh M 

PROVIDER: S-EPMC3842248 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature