Association of cytokine and Toll-like receptor gene polymorphisms with severe malaria in three regions of Cameroon.

ABSTRACT: P. falciparum malaria is one of the most widespread and deadliest infectious diseases in children under five years in endemic areas. The disease has been a strong force for evolutionary selection in the human genome, and uncovering the critical human genetic factors that confer resistance to the disease would provide clues to the molecular basis of protective immunity that would be invaluable for vaccine development. We investigated the effect of single nucleotide polymorphisms (SNPs) on malaria pathology in a case- control study of 1862 individuals from two major ethnic groups in three regions with intense perennial P. falciparum transmission in Cameroon. Twenty nine polymorphisms in cytokine and toll-like receptor (TLR) genes as well as the sickle cell trait (HbS) were assayed on the Seq

SUBMITTER: Apinjoh TO 

PROVIDER: S-EPMC3842328 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature