Sex differences in the neural and behavioral response to intranasal oxytocin and vasopressin during human social interaction.

ABSTRACT: Both oxytocin (OT) and vasopressin (AVP) are known to modulate social behavior, and dysfunction in both systems has been postulated as a potential cause of certain psychiatric disorders that involve social behavioral deficits. In particular, there is growing interest in intranasal OT as a potential treatment for certain psychiatric disorders, and preliminary pre-clinical and clinical studies suggest efficacy in alleviating some of the associated symptoms. However, the vast majority of research participants in these studies have been male, and there is evidence for sexually differentiated effects of nonapeptides in both humans and non-human animals. To date, no study has investigated the effect of intranasal OT on brain function in human males and females within the same paradigm. Previousl

SUBMITTER: Rilling JK 

PROVIDER: S-EPMC3842401 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature