Substitution rtq267h of hepatitis B virus increases the weight of replication and Lamivudine resistance.

ABSTRACT:

Background

Nucleus(t)ide analogs (NAs), containing Lamivudine (LMV), adefovir dipivoxil (ADV), endeavor (ETV), telbivudine (LdT), and tenofovir (TDF) are widely used for the treatment of chronic hepatitis B (CHB), but long term anti-Hepatitis B virus (HBV) therapy with NAs may give rise to the emergence of drug-resistant viral mutants.

Objectives

This study aimed to find and identify some new resistance mutations of HBV from the patients accepted anti-HBV therapy.

Patients and methods

The reverse transcriptase (RT) coding region of HBV was PCR-amplified using HBV DNA extracted from patients' blood samples and sequenced.

Results

Nineteen substitution mutations were detected. Among them, rtQ267H was often observed in patients receiving LMV administration. This LM

SUBMITTER: Qin B 

PROVIDER: S-EPMC3842524 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature