Methods and challenges in timing chromosomal abnormalities within cancer samples.

ABSTRACT:

Motivation

Tumors acquire many chromosomal amplifications, and those acquired early in the lifespan of the tumor may be not only important for tumor growth but also can be used for diagnostic purposes. Many methods infer the order of the accumulation of abnormalities based on their occurrence in a large cohort of patients. Recently, Durinck et al. (2011) and Greenman et al. (2012) developed methods to order a single tumor's chromosomal amplifications based on the patterns of mutations accumulated within those regions. This method offers an unprecedented opportunity to assess the etiology of a single tumor sample, but has not been widely evaluated.

Results

We show that the model for timing chromosomal amplifications is limited in scope, particularly for regions with high leve

SUBMITTER: Purdom E 

PROVIDER: S-EPMC3842754 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature