GPCR ontology: development and application of a G protein-coupled receptor pharmacology knowledge framework.

ABSTRACT:

Motivation

Novel tools need to be developed to help scientists analyze large amounts of available screening data with the goal to identify entry points for the development of novel chemical probes and drugs. As the largest class of drug targets, G protein-coupled receptors (GPCRs) remain of particular interest and are pursued by numerous academic and industrial research projects.

Results

We report the first GPCR ontology to facilitate integration and aggregation of GPCR-targeting drugs and demonstrate its application to classify and analyze a large subset of the PubChem database. The GPCR ontology, based on previously reported BioAssay Ontology, depicts available pharmacological, biochemical and physiological profiles of GPCRs and their ligands. The novelty of the GPCR ontol

SUBMITTER: Przydzial MJ 

PROVIDER: S-EPMC3842764 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature