Clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials.

ABSTRACT:

Objective

The purpose of this study was to investigate clinical gains from including both dextroamphetamine and methylphenidate in stimulant trials.

Method

Thirty-six medication-naïve children ages 9-14 years diagnosed with attention-deficit/hyperactivity disorder (ADHD) were enrolled for 6 weeks in a crossover trial, with 2 weeks of methylphenidate, dextroamphetamine, and placebo, in a randomly assigned, counterbalanced sequence. Outcome measures constituted a computer-based continuous performance test combined with a motion tracking system (Qb Test) and an ADHD questionnaire rated by parents and teachers.

Results

Group analyses found significant treatment effects of similar size for the two stimulants on both outcome measures. Single-subject analyses revealed that e

SUBMITTER: Ramtvedt BE 

PROVIDER: S-EPMC3842881 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature