Sibling donor and recipient immune modulation with atorvastatin for the prophylaxis of acute graft-versus-host disease.

ABSTRACT:

Purpose

Graft-versus-host disease (GVHD) is major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Atorvastatin is a potent immunomodulatory agent that holds promise as a novel and safe agent for acute GVHD prophylaxis.

Patients and methods

We conducted a phase II trial to evaluate the safety and efficacy of atorvastatin administration for GVHD prophylaxis in both adult donors and recipients of matched sibling allogeneic HCT. Atorvastatin (40 mg per day orally) was administered to sibling donors, starting 14 to 28 days before the anticipated first day of stem-cell collection. In HCT recipients (n = 30), GVHD prophylaxis consisted of tacrolimus, short-course methotrexate, and atorvastatin (40 mg per day orally).

Results

Atorva

SUBMITTER: Hamadani M 

PROVIDER: S-EPMC3842909 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature