The potential of antimicrobials to induce thrombocytopenia in critically ill patients: data from a randomized controlled trial.

ABSTRACT:

Background

Antimicrobial-induced thrombocytopenia is frequently described in the literature among critically ill patients. Several antimicrobials have been implicated, although experimental evidence to demonstrate causality is limited. We report, using a randomized trial, the potential of antimicrobials to induce thrombocytopenia.

Methods

Randomized trial allocated patients to antimicrobial treatment according to standard- of-care (SOC group) or drug-escalation in case of procalcitonin increases (high-exposure group). Patients were followed until death or day 28. Thrombocytopenia defined as absolute (platelet count ≤ 100 x 109/L) or relative (≥ 20% decrease in platelet count). Analyses were performed in the two randomized groups and as a merged cohort.

Results

Of the

SUBMITTER: Johansen ME 

PROVIDER: S-EPMC3842947 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature