HLA-A2, HLA-B44 and HLA-DR15 are associated with lower risk of BK viremia.

ABSTRACT:

Background

Human leucocyte antigens (HLAs) modulate immunity to polyomavirus BK (BKV). Identification of HLAs that alter the course of infection will facilitate risk stratification, and customization of pre-emptive intervention strategies.

Methods

We performed a retrospective cohort study with 998 kidney transplant patients with BKV infection status confirmed by polymerase chain reaction (PCR). Clinical parameters and donor-recipient matching for specific HLAs were examined in relation to occurrence of viremia. An emphasis was placed on donor-recipient matching rather than the actual frequency of specific HLA-alleles, since a successful immune response requires sharing of HLAs between a virus-infected target cell and the anti-viral effector cell.

Results

Using multiva

SUBMITTER: Masutani K 

PROVIDER: S-EPMC3843344 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature