Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus.

ABSTRACT:

Objective

We set out to characterize the clinical impact and functional consequences of rs1800693(G), the multiple sclerosis (MS) susceptibility allele found in the TNFRSF1A locus.

Methods

We analyzed prospectively collected data on patients with MS to assess the role of the TNFRSF1A locus on disease course and treatment response. Using archival serum samples and freshly isolated monocytes from patients with MS and healthy subjects, we evaluated the effects of rs1800693(G) and a second risk allele, R92Q, on immune function.

Results

In 772 patients with MS, we see no evidence that rs1800693(G) strongly influences clinical or radiographic indices of disease course and treatment response; thus, rs1800693(G) appears to be primarily involved in the onset of MS. At the mole

SUBMITTER: Ottoboni L 

PROVIDER: S-EPMC3843384 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature