Temporal trends in new exposure to antiepileptic drug monotherapy and suicide-related behavior.

ABSTRACT:

Objective

Because some recent studies suggest increased risk for suicide-related behavior (SRB; ideation, attempts) among those receiving antiepileptic drugs (AEDs), we examined the temporal relationship between new AED exposure and SRB in a cohort of older veterans.

Methods

We used national Veterans Health Administration databases to identify veterans aged ≥65 years who received a new AED prescription in 2004-2006. All instances of SRB were identified using ICD-9-CM codes 1 year before and after the AED exposure (index) date. We also identified comorbid conditions and medication associated with SRB in prior research. We used generalized estimating equations with a logit link to examine the association between new AED exposure and SRB during 30-day intervals during the year

SUBMITTER: Pugh MJ 

PROVIDER: S-EPMC3843385 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature