Cyclophilin A from Schistosoma japonicum promotes a Th2 response in mice.

ABSTRACT:

Background

Schistosomiasis is a chronic infection, where the host immune response to the parasite changes from a predominantly Th1 to Th2 phenotype, when parasite enters the egg stage, restraining the host inflammatory immune responses to achieve a longer survival in the host. On the other hand, the development of Th2 responses causes immunopathological changes such as liver fibrosis. Therefore identification of schistosome-derived Th2 inducing molecules is important in the understanding of pathogenesis of schistosomiasis. A cyclophilin A homologue of Schistosoma japonicum was reported to be an egg-stage specific antigen, but its immunogenicity and immunoregulatory activities remain unknown.

Methods

We cloned and expressed the gene of cyclophilin A from Schistosoma japonicum

SUBMITTER: Li J 

PROVIDER: S-EPMC3843525 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature