Characterization of regulatory features of housekeeping and tissue-specific regulators within tissue regulatory networks.

ABSTRACT:

Background

Transcription factors (TFs) and miRNAs are essential for the regulation of gene expression; however, the global view of human gene regulatory networks remains poorly understood. For example, how is the expression of so many genes regulated by limited cohorts of regulators and how are genes differentially expressed in different tissues despite the genetic code being the same in all tissues?

Results

We analyzed the network properties of housekeeping and tissue-specific genes in gene regulatory networks from seven human tissues. Our results show that different classes of genes behave quite differently in these networks. Tissue-specific miRNAs show a higher average target number compared with non-tissue specific miRNAs, which indicates that tissue-specific miRNAs tend

SUBMITTER: Li P 

PROVIDER: S-EPMC3843562 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature