A chronological expression profile of gene activity during embryonic mouse brain development.

ABSTRACT: The brain is a functionally complex organ, the patterning and development of which are key to adult health. To help elucidate the genetic networks underlying mammalian brain patterning, we conducted detailed transcriptional profiling during embryonic development of the mouse brain. A total of 2,400 genes were identified as showing differential expression between three developmental stages. Analysis of the data identified nine gene clusters to demonstrate analogous expression profiles. A significant group of novel genes of as yet undiscovered biological function were detected as being potentially relevant to brain development and function, in addition to genes that have previously identified roles in the brain. Furthermore, analysis for genes that display asymmetric expression between the l

SUBMITTER: Goggolidou P 

PROVIDER: S-EPMC3843766 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature