Regulation of FOXO3 by phosphorylation and methylation in hepatitis C virus infection and alcohol exposure.

ABSTRACT:

Unlabelled

Hepatitis C virus (HCV) infection produces chronic liver injury that is significantly exacerbated by alcohol consumption. While multiple mechanisms contribute to this synergy, a viral-induced loss of antioxidant responses has been shown to play an important role. This study examined the effects of HCV infection and alcohol on the regulation of the transcription factor FOXO3, an important regulator of Mn-superoxide dismutase (SOD2) expression, a tumor suppressor, and a component of the hepatic antioxidant response system. FOXO3 was activated by either HCV or alcohol alone but suppressed by the combination. To understand this paradoxical result, we applied a capillary isoelectric focusing (IEF) method to determine the pattern of FOXO3 posttranslational modifications (PTMs)

SUBMITTER: Tikhanovich I 

PROVIDER: S-EPMC3844049 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature