Genotyping and pathobiologic characterization of canine parvovirus circulating in Nanjing, China.

ABSTRACT:

Background

Canine parvovirus (CPV) is an important pathogen that causes acute enteric disease in dogs. It has mutated and spread throughout the world in dog populations. We provide an update on the molecular characterization of CPV that circulated in Nanjing, a provincial capital in China between 2009 and 2012.

Results

Seventy rectal swab samples were collected from the dogs diagnosed with CPV infection in 8 animal hospitals of Nanjing. Sequence analysis of VP2 genes of 31 samples revealed that 29 viral strains belonged to CPV-2a subtype, while other two strains were classified into CPV-2b. To investigate the pathogenicity of the prevalent virus, we isolated CPV-2a and performed the animal experiment. Nine beagles were inoculated with 105.86 of 50% tissue culture infectious

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC3844316 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature