Post-translational regulation enables robust p53 regulation.

ABSTRACT:

Background

The tumor suppressor protein p53 plays important roles in DNA damage repair, cell cycle arrest and apoptosis. Due to its critical functions, the level of p53 is tightly regulated by a negative feedback mechanism to increase its tolerance towards fluctuations and disturbances. Interestingly, the p53 level is controlled by post-translational regulation rather than transcriptional regulation in this feedback mechanism.

Results

We analyzed the dynamics of this feedback to understand whether post-translational regulation provides any advantages over transcriptional regulation in regard to disturbance rejection. When a disturbance happens, even though negative feedback reduces the steady-state error, it can cause a system to become less stable and transiently overshoots

SUBMITTER: Shin YJ 

PROVIDER: S-EPMC3844394 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature