Sex differences in kidney gene expression during the life cycle of F344 rats.

ABSTRACT:

Background

The kidney functions in key physiological processes to filter blood and regulate blood pressure via key molecular transporters and ion channels. Sex-specific differences have been observed in renal disease incidence and progression, as well as acute kidney injury in response to certain drugs. Although advances have been made in characterizing the molecular components involved in various kidney functions, the molecular mechanisms responsible for sex differences are not well understood. We hypothesized that the basal expression levels of genes involved in various kidney functions throughout the life cycle will influence sex-specific susceptibilities to adverse renal events.

Methods

Whole genome microarray gene expression analysis was performed on kidney samples coll

SUBMITTER: Kwekel JC 

PROVIDER: S-EPMC3844475 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature