Predicting treatment response in social anxiety disorder from functional magnetic resonance imaging.

ABSTRACT:

Context

Current behavioral measures poorly predict treatment outcome in social anxiety disorder (SAD). To our knowledge, this is the first study to examine neuroimaging-based treatment prediction in SAD.

Objective

To measure brain activation in patients with SAD as a biomarker to predict subsequent response to cognitive behavioral therapy (CBT).

Design

Functional magnetic resonance imaging (fMRI) data were collected prior to CBT intervention. Changes in clinical status were regressed on brain responses and tested for selectivity for social stimuli.

Setting

Patients were treated with protocol-based CBT at anxiety disorder programs at Boston University or Massachusetts General Hospital and underwent neuroimaging data collection at Massachusetts Institute of Techn

SUBMITTER: Doehrmann O 

PROVIDER: S-EPMC3844518 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature