Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs.

ABSTRACT:

Background

Despite their widespread use, the biological mechanisms underlying the efficacy of psychotropic drugs are still incompletely known; improved understanding of these is essential for development of novel more effective drugs and rational design of therapy. Given the large number of psychotropic drugs available and their differential pharmacological effects, it would be important to establish specific predictors of response to various classes of drugs.

Results

To identify the molecular mechanisms that may initiate therapeutic effects, whole-genome expression profiling (using 324 Illumina Mouse WG-6 microarrays) of drug-induced alterations in the mouse brain was undertaken, with a focus on the time-course (1, 2, 4 and 8 h) of gene expression changes produced by eighte

SUBMITTER: Korostynski M 

PROVIDER: S-EPMC3844597 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature