Virus-mimetic cytoplasm-cleavable magnetic/silica nanoclusters for enhanced gene delivery to mesenchymal stem cells.

ABSTRACT: It does get in: Phage is made of DNA as a core and protein as a coat, and it can transfer DNA into host cells with high efficiency. Phage-mimetic gene transfer to hard-to-transfect mesenchymal stem cells (MSCs) was achieved using virus-mimetic magnetic silica nanoclusters (VMSNCs). The VMSNCs bear MSC-homing phage-borne protein on the surface and encapsulate DNA inside, promoting the transfer of DNA into MSCs.

SUBMITTER: Gandra N 

PROVIDER: S-EPMC3844676 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature