Effect of birth weight on the association between necrotising enterocolitis and red blood cell transfusions in <=1500 g infants.

ABSTRACT:

Context

Reports evaluating a possible association between necrotising enterocolitis (NEC) and blood transfusion have been predominantly case-control studies. As the possible associations of disease with any variable on which cases and controls have been matched cannot be explored, a cohort study would offer a solution to this problem.

Objective

Our objective was to evaluate the association between exposure to a packed red blood cell (PRBC) transfusion and development of NEC in a cohort where biases of matching are omitted.

Design

In a retrospective cohort, exposed infants were defined as those who received a transfusion and did not develop NEC or developed NEC within 48 h of the transfusion. All others were considered unexposed.

Setting

A single regional perina

SUBMITTER: Elabiad MT 

PROVIDER: S-EPMC3845042 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature