Ontology highlight
ABSTRACT:
SUBMITTER: Li P
PROVIDER: S-EPMC3845444 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Nature neuroscience 20131020 12
It is generally believed that cerebellar granule neurons originate exclusively from granule neuron precursors (GNPs) in the external germinal layer (EGL). Here we identified a rare population of neuronal progenitors in mouse developing cerebellum that expresses Nestin. Although Nestin is widely considered a marker for multipotent stem cells, these Nestin-expressing progenitors (NEPs) are committed to the granule neuron lineage. Unlike conventional GNPs, which reside in the outer EGL and prolifer ...[more]