Diesel exhaust particle induction of IL-17A contributes to severe asthma.

ABSTRACT:

Background

IL-17A has been implicated in severe forms of asthma. However, the factors that promote IL-17A production during the pathogenesis of severe asthma remain undefined. Diesel exhaust particles (DEPs) are a major component of traffic-related air pollution and are implicated in asthma pathogenesis and exacerbation.

Objective

We sought to determine the mechanism by which DEP exposure affects asthma severity using human and mouse studies.

Methods

BALB/c mice were challenged with DEPs with or without house dust mite (HDM) extract. Airway inflammation and function, bronchoalveolar lavage fluid cytokine levels, and flow cytometry of lung T cells were assessed. The effect of DEP exposure on the frequency of asthma symptoms and serum cytokine levels was determined in c

SUBMITTER: Brandt EB 

PROVIDER: S-EPMC3845500 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature