HIV infection is associated with reduced pulmonary diffusing capacity.

ABSTRACT:

Introduction

Prior studies comparing abnormalities in pulmonary function between HIV-infected and HIV-uninfected persons in the current era are limited.

Objectives

To determine the pattern and severity of impairment in pulmonary function in HIV-infected compared with HIV-uninfected individuals.

Methods

Cross-sectional analysis of 300 HIV-infected men and 289 HIV-uninfected men enrolled from 2009 to 2011 in 2 clinical centers of the Lung HIV Study. Participants completed pre- and postbronchodilator spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) measurement, and standardized questionnaires.

Results

Most participants had normal airflow; 18% of HIV-infected and 16% of HIV-uninfected men had airflow obstruction. The mean percent predicted DLCO

SUBMITTER: Crothers K 

PROVIDER: S-EPMC3845879 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature