Storable palladacycles for selective functionalization of alkyne-containing proteins.

ABSTRACT: We report the facile preparation of palladacycles as storable arylpalladium(II) reagents from acetanilides via cyclopalladation. The palladacycles exhibit good stability in PBS buffer and are capable of functionalizing a metabolically encoded HPG-containing protein, thus providing a new type of biocompatible organometallic reagent for selectively functionalizing the alkyne-encoded proteins.

SUBMITTER: Cheng G 

PROVIDER: S-EPMC3845886 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature