Improving metabolic parameters of antipsychotic child treatment (IMPACT) study: rationale, design, and methods.

ABSTRACT:

Background

Youth with serious mental illness may experience improved psychiatric stability with second generation antipsychotic (SGA) medication treatment, but unfortunately may also experience unhealthy weight gain adverse events. Research on weight loss strategies for youth who require ongoing antipsychotic treatment is quite limited. The purpose of this paper is to present the design, methods, and rationale of the Improving Metabolic Parameters in Antipsychotic Child Treatment (IMPACT) study, a federally funded, randomized trial comparing two pharmacologic strategies against a control condition to manage SGA-related weight gain.

Methods

The design and methodology considerations of the IMPACT trial are described and embedded in a description of health risks associated with

SUBMITTER: Reeves GM 

PROVIDER: S-EPMC3846140 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature