Protein WISDOM: a workbench for in silico de novo design of biomolecules.

ABSTRACT: The aim of de novo protein design is to find the amino acid sequences that will fold into a desired 3-dimensional structure with improvements in specific properties, such as binding affinity, agonist or antagonist behavior, or stability, relative to the native sequence. Protein design lies at the center of current advances drug design and discovery. Not only does protein design provide predictions for potentially useful drug targets, but it also enhances our understanding of the protein folding process and protein-protein interactions. Experimental methods such as directed evolution have shown success in protein design. However, such methods are restricted by the limited sequence space that can be searched tractably. In contrast, computational design strategies allow for the screening of a

SUBMITTER: Smadbeck J 

PROVIDER: S-EPMC3846368 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature