Invasive breast cancer in Argentine women: association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature.

ABSTRACT:

Objective

In breast cancer, several tumor markers have been identified. The marker most extensively associated with breast cancer is MUC1. The objective of the study was to analyze prognostic and risk factors in relation to tumor markers in order to clarify breast cancer biology. A total of 349 primary tumor samples and lymph nodes from breast cancer patients were studied. Risk and prognostic factors were considered. An immunohistochemical approach was applied and an extensive statistical analysis was performed, including frequency analysis and analysis of variance. Correlation among variables was performed with principal component analysis.

Results

All the antigens showed an increased expression according to tumor size increment; moreover, sialyl Lewis x expression showed a

SUBMITTER: Demichelis SO 

PROVIDER: S-EPMC3846659 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature