The role of retinoic acid in hepatic lipid homeostasis defined by genomic binding and transcriptome profiling.

ABSTRACT:

Background

The eyes and skin are obvious retinoid target organs. Vitamin A deficiency causes night blindness and retinoids are widely used to treat acne and psoriasis. However, more than 90% of total body retinol is stored in liver stellate cells. In addition, hepatocytes produce the largest amount of retinol binding protein and cellular retinoic acid binding protein to mobilize retinol from the hepatic storage pool and deliver retinol to its receptors, respectively. Furthermore, hepatocytes express the highest amount of retinoid x receptor alpha (RXRα) among all the cell types. Surprisingly, the function of endogenous retinoids in the liver has received very little attention.

Results

Based on the data generated from chromatin immunoprecipitation followed by sequencing, the

SUBMITTER: He Y 

PROVIDER: S-EPMC3846674 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature